SPRAVATO®

Treatment-resistant depression can deeply affect your daily life, especially when standard antidepressants don’t provide enough relief. If your symptoms persist despite trying multiple medications, psychiatrist Margaret Miller, DNP, LMSW, and the team at Greenwich Avenue Psychiatry in Greenwich, Connecticut, offer SPRAVATO® (esketamine) — an innovative, FDA-approved therapy for adults with treatment-resistant depression. Call the office to schedule an evaluation or request an in-person or telehealth consultation online today. Telehealth services are available to patients throughout New York and Connecticut.

What is SPRAVATO®?

SPRAVATO® (esketamine) is a prescription nasal spray designed for adults with treatment-resistant depression. It works differently from traditional antidepressants by targeting glutamate, a key neurotransmitter involved in mood regulation. This unique mechanism allows SPRAVATO to create rapid changes in brain pathways associated with depression, helping many patients experience relief sooner than with standard medications.

SPRAVATO is always administered under medical supervision in a certified treatment center. After each session, the team monitors you for a short period to ensure your safety and comfort before you return home with an approved ride.

Who is a candidate for SPRAVATO®?

You may be a good candidate for SPRAVATO if you:

• Have tried at least two antidepressant medications without significant improvement
• Experience persistent depressive symptoms that interfere with daily functioning
• Are currently taking an oral antidepressant, which is required alongside SPRAVATO
• Prefer a treatment option that works faster than traditional medications

The team performs a comprehensive mental health assessment to determine whether SPRAVATO is appropriate and safe for you.

What are the benefits of SPRAVATO®?

SPRAVATO offers several advantages for people with treatment-resistant depression, including:

• Rapid symptom improvement, often within hours to days
• Reduced suicidal thoughts in adults with major depressive disorder (MDD)
• A new mechanism of action for patients who haven’t responded to standard medications
• Guided, in-office administration ensuring careful monitoring and support

Many patients describe feeling a noticeable shift in mood, clarity, or emotional heaviness after the first few treatments.

What should I expect during SPRAVATO® treatment?

SPRAVATO treatments take place in a calm, private space at Greenwich Avenue Psychiatry.

During each session:

1. You self-administer the nasal spray under clinical supervision.
2. You relax in a comfortable treatment room while the team monitors your blood pressure and overall response.
3. You remain on-site for about two hours for observation.
4. You can go home afterward with a trusted support person to drive you.

Your provider will review your response over time and adjust your treatment plan as needed to ensure the best results.

Call Greenwich Avenue Psychiatry or request an appointment online today to learn whether SPRAVATO® is the right treatment for you.